Intestinal barrier dysfunction and alcoholic liver disease
نویسندگان
چکیده
منابع مشابه
Adipose Tissue Dysfunction and Alcoholic Liver Disease
Although much progress has been made over last three decades of research on the mechanisms underlying alcoholic liver disease (ALD), it remains an important health problem in the United States. ALD ranks among the major causes of morbidity and mortality in the world, and affects millions of patients worldwide each year [1]. The disease process is characterized by early steatosis, steatohepatiti...
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A significant body of evidence indicates that endotoxemia and endotoxin-mediated hepatocellular damage play a crucial role in the pathogenesis of alcoholic liver disease. A close correlation between endotoxemia and the severity of alcohol-induced liver injury is supported by a number of clinical and experimental studies. Elevated intestinal permeability appears to be the major factor involved i...
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Maintenance of intestinal barrier integrity is crucial for preventing inflammatory bowel 15 diseases (IBDs) onset and exacerbations. In this work we study the effect of a fixed combination of 16 Lactobacillus reuteri and Lactobacillus acidophilus and herbal extracts in an in vitro inflammation 17 experimental model. Caco-2 cell monolayer was exposed to INF-γ+TNF-α or to LPS; Trans Epithelial 18...
متن کاملIntestinal fungi contribute to development of alcoholic liver disease.
Chronic liver disease with cirrhosis is the 12th leading cause of death in the United States, and alcoholic liver disease accounts for approximately half of all cirrhosis deaths. Chronic alcohol consumption is associated with intestinal bacterial dysbiosis, yet we understand little about the contribution of intestinal fungi, or mycobiota, to alcoholic liver disease. Here we have demonstrated th...
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Non-alcoholic fatty liver disease (NAFLD) is an asymptomatic increasingly common disorder that affects liver metabolism and is often the precursor for liver pathologies such as fibrosis, cirrhosis and hepato-cellular carcinoma. The liver sinusoidal endothelial cells act as a liver sieve by allowing macromolecules and chylomicrons to traverse through their fenestrations (sieve plates) to hepatoc...
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ژورنال
عنوان ژورنال: World Chinese Journal of Digestology
سال: 2019
ISSN: 2219-2859
DOI: 10.11569/wcjd.v27.i19.1179